hrp0082p1-d3-15 | Adrenals & HP Axis (1) | ESPE2014

Testicular Adrenal Rest Tumors and Sertoli Cell Function in Adolescents with Cah

Chugunov Igor , Kareva Maria , Orlova Elizaveta , Kuznecova Elvira , Bogolubov Sergey

Background: Infertility is one of the major problems in adult males with congenital adrenal hyperplasia (CAH), associated with the development of testicular adrenal rest tumors (TART). Sertoli cell dysfunction could be diagnosed not only in adults but in adolescence.Objective and Hypotheses: To study Inhibin B and AMH levels in adolescents with CAH and TART and its diagnostics value in access of Sertoli cell function.Method: We stu...

hrp0084p3-583 | Adrenals | ESPE2015

Insufficient Mineralocorticoid Replacement as a Predictor Factor for the TART in Boys with Congenital Adrenal Hyperplasia

Chugunov Igor , Kareva Maria , Orlova Elizaveta , Kuznecova Elvira

Background: Testicular adrenal rest tumor (TART) is one of the main causes of decreased fertility in men with congenital adrenal hyperplasia (CAH). TART may occurs in childhood but there is no currently identified factors influencing the development of this condition.Objective and hypotheses: To study the role of glucocorticoid and mineralocorticoid undertreatment in the TART development in children and adolescents with CAH, 21-hydroxylase deficiency.</p...